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Mogie Singh
Dr. Mogie Singh PHD( Biochemistry)
Contact details
Tel: 031 260 7170
Email: singhm1@ukzn.ac.za
Physical address: Department of Biochemistry
Block F3 Room 12
Westville Campus
Chiltern Hills
Westville
3830
Research interests:
Therapeutic Nanotechnology
RNAi Therapeutics
Liposome technology
Non-viral gene delivery
Mammalian Tissue culture
Current Research:
- Formulation and characterisation of non-viral gene delivery vectors viz. liposomes
- Evaluation of non-viral vectors in vitro and in vivo.
- Recent work involves the evaluation of synthetic nanomaterials in gene delivery
- Collaborative interests: Prof Mario Ariatti (UKZN, Biochemistry,Westville)-
Non-viral gene delivery and Nanotechnology.
Dr. B. Masola (UKZN, Biochemistry,Westville)-
Targeted mitochondrial gene delivery.
Prof Patrick Arbuthnot (Wits University) – Therapeutic use of liposomes in Nanotechnology.
Dr. Sooboo Singh (Chemistry, UKZN, Westville) – Evaluation of synthetic nanomaterials in gene delivery.
Society Membership:
1. South African Society of Biochemistry and Molecular Biology
2. European Society of Gene and Cell Therapy
Publications (2001-2009)
- M.Singh, N.Kissoon and M.Ariatti. (2001). “Receptor- mediated Gene Delivery to HepG2 Cells by Ternary Assemblies containing Cationic Liposomes and Cationized Asialoorosomucoid”. Drug Delivery. 8 : 29-34.
- M.Singh, S.Balram, M.Ariatti. (2001). “Lipoplex – Mediated Stable Gene Transfer into HeLa Cells”. Nucleotides, Nucleosides and Nucleic Acids.20 : Issue 4-7.
- S.Singh, J.A. Nevines, M.Singh, M.Ariatti, M Sankar. (2003). “Thermodynamic properties of Alanylpeptide Buffer Systems and Their Potential as Standards in Biological Applications”. Journal of Solution Chemistry. 32 : 5 : 435-450.
- M. Singh and M.Ariatti. (2003).”Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes”. Journal of Controlled Release. 92 : 3: 383-394.
5. M. Singh and M. Ariatti. (2006) “A cationic cytofectin with long spacer mediates favourable transfection in transformed human epithelial cells”. International Journal of Pharmaceutics. 309: 189-198.
6. M. Singh, A. Hawtrey and M. Ariatti. (2006) “Lipoplexes with biotinylated transferrin
accessories : Novel, targeted, serum-tolerant gene carriers”. International Journal of
Pharmaceutics. 321: 124-137.
7. M.Singh,B.C.Rogers and M. Ariatti (2007). “Targeting of glycosylated lipoplexes in
HepG2 cells: Anomeric and C-4 epimeric preference of the asialoglycoprotein
receptor". South African Journal of Science. 103 : 204-210.
8. M.Singh and M. Ariatti (2008). “Cholesteryl cytofectins with primary amino head
group transfect transformed human epithelial cell lines efficiently”. Drug Delivery.
15 : 97-105
9. Mackraj I; Ramesar S; Singh M; Govender T; Baijnath H; Singh R and Gathiram P
(2008). “ The in vivo effects of Tulbhagia violacea on blood pressure in a salt-sensitive
rat model”. Journal of Ethnopharmacology . 117(2): 263-269.
10. S.Balram , M. Ariatti, M.Singh and V. Rambiritch (2009). “Cholesteryl cytofectin-
Oligodeoxyribonucleotide lipoplexes: Protection against serum nuclease
digestion and interaction with mammalian cells in vitro”. African Journal of Biotechnology Vol. 8 (16): 3904-3910
Published Proceedings and Abstracts
- T.Moodley, M.Singh, N.Kisoon, Y. Naidoo and M. Ariatti. (2002). “Structure of Lipoplexes derived from Novel Cationic Liposomes and DNA”. Proceedings of the 15th International Congress on Electron Microscopy. 2 : 815-816.
2. M. Singh, M. Ariatti, P. Arbuthnot and S.M. Mufamadi. (2006) “Lipoplex formation by
synthetic targeted cationic liposome- mediated DNA carrier systems”. Proceedings of
the 16th International Microscopy Congress. 1 : 56.
3. A.Singh, M. Singh, M.Ariatti and R. Naidoo (2007). “Modular approach to biotin-
directed assembly of targeted hepatocyte gene delivery complexes”. Human Gene
Therapy. 18 (10): 1034-1035
4. M. Singh and M. Ariatti (2008). “Cationic Liposome Mediated Glycotargeting to
Hepatocytes”. Human Gene Therapy. 19 (10): 1118