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The School has extensive international experience - Canada, Australia, New Zealand, the U.S. and the U.K.. Recent publications - adult education in mathematics, a definitive Biochemical guide to “Protein Isolation” and articles in leading international scientific journals.
Publications of Professor Theresa Coetzer
Troeberg, L., Chen, X., Flaherty, T.M., Morty, R.E., Cheng, M., Hua, H., Springer, C., McKerrow, J.H., Kenyon, G.L., Lonsdale-Eccles, J.D., Coetzer, T.H.T. and Cohen, F.E. (2000) Chalcone, acyl hydrazide and related amides kill cultured Trypanosoma brucei brucei. Mol. Med. 6, 660-669.
Morty, R.E., Troeberg, L., Powers, J. C., Ono, S., Lonsdale-Eccles, J. D. and Coetzer, T.H.T. (2000) Characterisation of the antitrypanosomal activity of peptidyl a-aminoalkyl phosphonate diphenyl esters. Biochem. Pharmacol. 60, 1497-1504.
Morty, R.E., Lonsdale-Eccles, J. D., Mentele,R., Auerswald,E.A. and Coetzer, T.H.T (2001) Trypanosome-derived oligopeptidase B is released into the plasma of infected rodents, where it persists and retains full catalytic activity. Infect. Immun. 69, 2757-2761.
Irving JA, Shushanov SS, Pike RN, Popova EY, Bromme D, Coetzer TH, Bottomley SP, Boulynko IA, Grigoryev SA and Whisstock JC (2002) Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem. 277, 13192-131201.
Irving JA, Pike RN, Dai W, Bromme D, Worrall DM, Silverman GA, Coetzer TH, Dennison C, Bottomley SP and Whisstock JC (2002) Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases. Biochemistry. 41, 4998-5004.
Publications of Dr Edith Elliott
Elliott, E. and Dennison, C. (1990) Analysis of colloidal gold probes by isoelectric focusing in agarose. Analyt. Biochem. 186, 53-59.
Coetzer T.H.T., Elliott, E., Fortgens, P.H., Pike, R.N. and Dennison, C. (1991) Peptide antibodies to cathepsins B, L and D and collagenase IV: specific recognition and inhibition of the enzymes. J. Immunol. Methods 136, 199-210.
Morewood, C.R., Elliott, E., Dennison, C. and Bruton, A.G. (1992) Further modification of the LKB 7800 series KnifeMaker for improved reproducibility in breaking "cryo" knives. J. Microsc., 168, 111-114.
Moin, K., Sameni, M., Elliott, E., Ziegler, G. and Sloane, B.F. (1994) Ras oncogene alters localization of cathepsins. In: Proteinases involved in cancer. Suzuki, M and Hiwasa, T. eds. Monduzzi Editore, Bologna, Italy. pp. 51-58.
Elliott, E., Dennison, C., Fortgens, P.H. and Travis, J. (1995) Paraformaldehyde fixation of neutrophils for immunolabelling of granule antigens in "cryo"-ultrasections. J. Histochem. Cytochem. 43, 1019-1025.
Sameni, M., Elliott, E., Ziegler, G., Fortgens, P.H., Dennison, C. and Sloane, B.F. (1995) C-Ha-Ras oncogenically differentially affects subcellular distribution of cathepsins in breast epithelial cells. Pathology and Oncology Research, 1, 43-53.
Dehrmann, F.M., Elliott, E. and Dennison, C. (1996) Reductive activation markedly increases the stability of cathepsins B and L to extracellular ionic conditions. Biol. Chem. Hoppe Seyler, 377, 391-393.
Elliott, E. and Sloane, B.F. (1996) The cysteine protease cathepsin B in cancer. Perspectives in Drug Discovery and Design, 6, 12-32.
Fortgens, P.H., Dennison, C. and Elliott, E. (1997) Anti-cathepsin D chicken IgY antibodies: characterisation, cross-species reactivity and application to immunogold labelling studies of human neutrophils and other tissues. Immunopharmacology, 36, 305-311.
Price, B., Dennison, C., Tschesche, H. and Elliott, E. (2000) Neutrophil tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) is found in novel granules that do not fuse with the phagosome. J. Biol. Chem. 275, 28308-281315.
Pillay, C., Elliott, E. and Dennison, C. (2002) Endolysosomal proteolysis and its regulation Biochem. J. 363 (3) 417-429.
Published abstracts (last 3 years)
Elliott, E., Dennison, C., Sameni, M. and Ahram, M. (1997) Cathepsin B and D and malignancy. FASEB J., 11, A1357, 2494.
Price, B., Dennison, C. and Tschesche, H. (1997) Cryo-immunocytochemical localisation of TIMP-1 with respect to pro-MMPs and granule marker proteins in neutrophils. Microsc. Soc. S.A., 27, 98.
Jackson, J.G., Bandu, V.H., Dennison, C. and Elliott, E. (1999) In vivo pH determination using 3-(2,4-dinitroanilino)-3’-amino-N-methyldipropyl-amine (DAMP). Microsc. Soc. S.A., 29, 89.
Steart, C.M., White, B.J., Bandu, V.H. and Elliott, E. (1999) Tubular early endosomal systems in the MCF-10A cell line and ite ras-transfected derivative. Microsc. Soc. S.A., 29, 87.
Edwards V A, Elliott E, Bandu V, Pillay V L, Swart P and Singh S (2002) Immunolocalization of xylanase on polysulphone membranes. Microsc. Soc. S.A., 31, 52.
Publications of Professor Dean Goldring
J.P. Dean Goldring (2002) Antimalarial drugs do not “hide” malaria parasites from laboratory detection. South African Medical Journal, 92, 395.
J.A Verschoor and J.P.Dean Goldring(1997) Biochemistry in S.A.: a survey of career opportunities. South African Journal of Science 93, 4.: [Journal article]
J.P. Dean Goldring (December 1999) Biochemists of the Century The Biochemist 12. [Journal article]
J.P. Dean Goldring (1999) Biochemists of the Century The Biochemist December: 12. [Journal article]
J.P. Dean Goldring (1998) SA Universities are not that bad Prof .... In: Sunday Times (S.A.), pp. 28, [Report]
J.P. Dean Goldring and Nat Ramoshebi(1999) Glucocorticoids, antioxidants and staurosporine modulate the adherence between monocytes and malaria infected erythrocytes Inflammation Research 48: 657 - 661. [Journal article]
J.P. Dean Goldring, T. Padayachee and I. Ismail(1999) Plasmodium falciparum malaria: Rosettes are disrupted by quinine, artemesinin, mefloquine, primaquine, pyrimethamine, chloroquine and proguanil Memorias do Instituto Oswaldo Cruz 94: 667-674. [Journal article]
J.P.Dean Goldring (December 2 1999) Malaria on the run ? In: Natal Witness Newspaper (SA), pp. 25, [Report]
J.P.Dean Goldring (1997) Value for money Nature 386, 542. [Journal article]
J.P.Dean Goldring(1997) Judging the value of science In: Chemistry and Industry, Vol. 9, pp. 366 , [Book]
J.P.Dean Goldring(1999) Biotechnology Degree in South Africa. In: Biochemistry Education, Vol. 27, pp. 35-36, [Book]
J.P.Dean Goldring (24 July 1999) Can Carrots fight off Malaria ? In: Natal Witness Newspaper (S.A.), pp. 12, [Report]
J.P.Dean Goldring (November 1999) Did Bugs Bunny know something about malaria prevention In: The Getaway travel magazine (SA), pp. 41, [Report]
J.P.Dean Goldring (1997) Value for money Nature 386, 542. [Journal article]
J.P.Dean Goldring (1997) Judging the value of science. Chemistry and Industry 9: 366. [Journal article]
J.P.Dean Goldring (1999) Biotechnology Degree in South Africa Biochemistry Education 27: 35-36. [Journal article]
J.P.Dean Goldring (1 October 1999) Lipids in TB offer hope for vaccine In: Natal Witness Newspaper (S.A), pp. 19, [Report]
J.P.Dean Goldring and Sharon Nemaorani (1999) Antimalarial drugs modulate the expression of monocyte receptors International Journal of Immunopharmacology 21: 599 - 607. [Journal article]